CLINICAL

Exercise Capacity and Quality of Life in GOLD II-IV COPD

We studied 22 COPD (GOLD II-IV) patients, in a cross-over controlled, double blind, randomized study with 2 weeks of treatment. Results demonstrated an unprecedented improvement of 6 minutes walk distance (62m), and significant improvement in FVC and IC lung functions, as well as significant improvement in Dyspnea and Mastery quality of life questionnaire scores. The results were published in Journal of COPD. Fridlender et. al.,  

"Randomized Controlled Crossover Trial of a New Oscillatory Device as Add-On Therapy for COPD", J COPD 2012

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Drug Delivery with Pulsehaler 

"Acoustic Pressure Pulsations Enhance Peripheral Aerosol Distribution and the Bronchodilating Effects of Albuterol in COPD" was a pilot crossover controlled study of the effects of adding Pulsehaler technology to nebulized drug delivery. The delivery was measured by imaging using radio-labeled albuterol. The results showed a significant enhancement in penetration index when compared to administration with a standalone nebulizer.

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Co-funded by the Horizon 2020 programme of the European Union